Navigating and expanding the roadmap of natural product genome mining tools

• Friederike Biermann,
• Sebastian L. Wenski and
• Eric J. N. Helfrich

Beilstein J. Org. Chem. 2022, 18, 1656–1671, doi:10.3762/bjoc.18.178

• combination of all genome mining approaches will pave the way towards a more comprehensive understanding of the full biosynthetic repertoire encoded in microbial genome sequences. Keywords: genome mining; natural product biosynthesis; non-canonical pathways; PKS; NRPS; RiPP; Introduction In 2002, the genome

• potential strategies for the targeted identification of non-canonical pathways to chart the full biosynthetic potential encoded in bacterial genomes. Perspective Natural product biosynthetic principles NPs are structurally highly diverse and can be divided into several classes depending on their

• two putative solutions to complement existing approaches to expand NP biosynthetic space and to chart biosynthetic dark matter. Genome-wide characterization of all clustered genes as an approach to identify non-canonical pathways One concept that is based on the above outlined indirect approach is the